Assignments got your hair on fire?

Douse the flames with our full-range writing service!

Experienced academic writing professionals are at your fingertips. Use this handy tool to get a price estimate for your project.

1,6-Hexanediamine, polymer with (chloromethyl)oxirane

Here we demonstrate the synthesis of multifunctionalised benzimidazoles through the coupling of o-phenylenediamine with aldehydes by using Copper (II) hydroxide as an efficient solid catalyst in methanol at room temperature. The Copper (II) hydroxide solid catalyst gave better yields (80% - 99%) in short reaction time (4 - 8 h). These commercially available cheap catalysts are more active than many reported expensive heterogeneous catalysts. Using the Copper hydroxide fresh catalyst, the yield of product 3a was 98%, while the recovered catalyst in the three subsequent cycles gave the yield of 94%, 90% and 88% respectively.

Encouraged by these results, we examined several substituted aldehydes including aromatic, heteroaromatic and aliphatic groups, which underwent smooth conversion to afford a wide range of benzimidazoles (). Aromatic aldehydes containing both electron-donating and electron-withdrawing groups worked well in this reaction. Unfortunately metal hydroxides are not explored much in the synthesis of various benzimidazoles. It was found that transition metal oxide is more effective for oxidation than the corresponding zero-valent metal powders. Open air and copper hydroxide both may be sources for the oxidation process. Here, it seems that copper hydroxide solid catalyst is acting as bifunctional like Lewis acid as well as oxidative reagent.

 . A plausible mechanism for the synthesis of multifunctionalised benzimidazoles using Cu(OH)2.

Formaldehyde, polymer with (chloromethyl)oxirane and phenol

Hexanedioic acid, polymer with N-(2-aminoethyl)-N′-[2-[(2-aminoethyl)amino]ethyl]-1,2-ethanediamine, N-(2-aminoethyl)-1,2-ethanediamine and (chloromethyl)oxirane, sulfate

Polymer of 4,4′-(1-methylethylidene)bisphenol polymer with (chloromethyl)oxirane, 4,4′-(1-methylidene)bisphenol, alkylphenols, alkanolamines and alkylamines, lactic acid salt of

1,3-Propanediamine, N,N-dimethyl-, polymer with (chloromethyl)oxirane

Phenol, 4,4′-(1-methylethylidene)bis-, polymer with 4-amino-α,α,4-trimethylcyclohexanemethanamine, 5-amino-1,3,3-trimethylcyclohexanmethanamine, (chloromethyl)oxirane, 2,2,4-trimethyl-1,6-hexanediamine and 2,4,4-trimethyl-1,6-hexanediamine

68. Shin D, Lee SC, Heo YS, Lee WY, Cho YS, Kim YE. . Design and synthesis of 7-hydroxy-1H-benzoimidazole derivatives as novel inhibitors of glycogen synthase kinase-3beta. 2007;17:5686-9

Versatile Services that Make Studying Easy
We write effective, thought-provoking essays from scratch
We create erudite academic research papers
We champion seasoned experts for dissertations
We make it our business to construct successful business papers
What if the quality isn’t so great?
Our writers are sourced from experts, and complete an obstacle course of testing to join our brigade. Ours is a top service in the English-speaking world.
How do I know the professor won’t find out?
Everything is confidential. So you know your student paper is wholly yours, we use CopyScape and WriteCheck to guarantee originality (never TurnItIn, which professors patrol).
What if it doesn’t meet my expectations?
Unchanged instructions afford you 10 days to request edits after our agreed due date. With 94% satisfaction, we work until your hair is comfortably cool.
Clients enjoy the breezy experience of working with us
Click to learn our proven method

2-Chloromethyl-1H-benzimidazole-4-carboxylic acid - …

2-Chloromethyl-1H-benzimidazole-4-carboxylic acid.

In summary, benzimidazole and its derivatives were synthesized by the coupling of o-phenylenediamine with various aldehydes using commercially available Cu(OH)2 as an efficient recyclable solid catalyst under open oxygen atmosphere at room temperature using methanol as solvent. Various multifunctionalised Benzimidazoles could successfully be synthesized by using the Cu(OH)2 catalyst with acid sensitive, sterically hindered and substituted aromatic and aliphatic aldehydes. The reactions were performed in methanol and the catalyst could be reused for several cycles without much decrease in activity. The salient features of the present method include mild conditions, short reaction times, high yields, recyclable catalyst, large scale synthesis and simple procedure. These catalysts could replace the existing homogeneous and expensive heterogeneous catalysts which are currently being used in the synthesis of various industrially important and biologically active benzimidazoles.

The key starting material 2-(chloromethyl)-1H-benzimidazole (1) ..

In addition we have also carried out scale up experiments with 1.08 g of o-phenylenediamine and 1.27 g of benzaldehyde using 10 mol% of Copper hydroxide catalyst at room temperature in methanol. The Cu(OH)2 catalyst gave 98% of product 3a, that is almost similar to the yield obtained in Entry a, indicating that the catalyst could be easily used on a large scale. In the present work, the catalytic activity of the Cu(OH)2 has been studied for synthesis of multifunctionalised benzimidazole derivatives at room temperature. It has been found that these commercially available catalysts are very cheap, recyclable and showed superior activity at room temperature than Co(III) salen [48], and cheaper than many other expensive heterogeneous catalysts [32,33]. All the synthesized compounds (3a-3v) colour, melting points were checked and characterized by using IR and 1H-NMR spectra data was given below.


Many heterogeneous catalysts [32,33] and expensive Co(III) salen complexes [48] were used in the synthesis of various benzimidazoles. But all they have not achieved the products using aliphatic aldehydes. The present catalyst is simple, recyclable, green catalyst and more convenient than many catalysts presented in the above introduction. These catalysts were also found to be very active in the synthesis of benzimidazoles using an acid sensitive furfuraldehyde (3f) and bulky naphthaldehyde (3g), also worked well. Various substituted aldehydes have been used with similar success to provide the corresponding benzimidazoles in high yields (80% - 99%).


4,4′-(1-Methylethylidene)bisphenol, polymer with (chloromethyl)oxirane, and 2(dimethylamino)ethanol-blocked polyalkylenepolyphenylene isocyanate, lactates (salts)

of clients claim significantly improved grades thanks to our work.
of students agree they have more time for other things thanks to us.
Clients Speak
“I didn’t expect I’d be thanking you for actually improving my own writing, but I am. You’re like a second professor!”