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Olefin cross metathesis - Format: PDF

With improvements in metal-carbene initiators, the reaction became more widely used. Schrock and Grubbs led efforts to develop the catalysts that now allow olefin metathesis to flourish. Schrock's catalysts are based on molybdenum; Grubbs's are based on ruthenium and are widely credited with having put olefin metathesis in the hands of synthetic chemists because the catalysts are easy to use. "Chemists now routinely use the catalysts to prepare pharmaceutical candidates and new materials in an efficient and environmentally friendly way," says Jeremy M. Berg, director of the , which has supported the research of the American winners.

The reaction was first observed in the 1950s, but it wasn't until 1971 that a convincing mechanism was proposed. Chauvin and student Jean-Louis Hérisson suggested that the reaction is initiated by a metal carbene, which reacts with an olefin to form a new olefin and a new metal carbene, which propagates the reaction. Other chemists shed further light on the mechanism, which put the reaction on the path of practicality. For example, work in 1975 by Columbia University chemistry professor and graduate student James McGinnis led them to synthesize discrete metal-carbene complexes, which they used to initiate the reaction ().

Application of Olefin Cross Metathesis in Natural Product Syntheses. TU Berlin

Olefin metathesis: Reaction and Mechanism - Chemistry

Olefin Cross Metathesis

Melanie Sanford grew up in Providence, RI. She received her undergraduate degree in chemistry from Yale University in 1996 where she worked with Professor Bob Crabtree studying C-F bond functionalization. She then moved to Caltech where she worked with Professor Bob Grubbs investigating the mechanism of ruthenium-catalyzed olefin metathesis reactions. After receiving her PhD in 2001, she worked with Professor Jay Groves at Princeton University as an NIH post-doctoral fellow studying metalloporphyrin-catalyzed functionalization of olefins. Melanie has been a professor at the University of Michigan since the summer of 2003.

For years, the chemistry community has recognized the importance and utility of olefin metathesis. Now, the has chosen to recognize it, too: Last week, the academy awarded the to three chemists who developed the reaction—Yves Chauvin of the French Petroleum Institute, Rueil-Malmaison, France; of California Institute of Technology; and of Massachusetts Institute of Technology. They will share equally the $1.3 million prize.

Topic: Grubbs Ring Closing Metathesis Mechanism – 293537

The Swedish academy's choice "confirms what is generally agreed upon in the synthetic chemistry community—that olefin metathesis is a very useful catalytic reaction that has a broad scope," comments Harvard University chemistry professor and Nobel Laureate .

Total Synthesis of Stemoamide using ring-closing-metathesis - a comparison. Dissertation, 2006. University of Regensburg

According to the Swedish academy, olefin metathesis is a "great step forward for 'green chemistry.' " That statement reinforces the message that the best chemists in the world are doing green chemistry and that green chemistry is simply part of doing good chemistry, says Paul T. Anastas, director of the American Chemical Society's Green Chemistry Institute.

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Grubbs Ring Closing Metathesis Mechanism ..

Grubbs Ring Closing Metathesis Mechanism

In olefin metathesis, two carbon-carbon double bonds react to form two new carbon-carbon double bonds. In the process, substituents attached to the carbon atoms involved are exchanged. This exchange can result in various outcomes, including straight swapping of substituents, closure of large rings, formation of dienes, and polymerization. The reaction, which is catalytic, takes place under mild conditions and is so general that it is widely applicable.

Shell higher olefin process - Wikipedia

Olefin metathesis catalysts and technology are available from Materia, a company based in Pasadena, Calif., that was founded by Grubbs and for which both Grubbs and Schrock are scientific advisers.

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