Synthesis of α-Bromo ethyl aceto acetate (II): Mix 1.5 mM of ethyl aceto acetate (I), 7.5 mM of KBr, 7.5 ml of 1M HCl and 7.5 ml of tolune then stir them well at room temperature and add saturated solution of NaHCO3 sufficiently finally extracted with ethyl acetate.
Synthesis of Ethyl 2-(4-(4-substituted) benzyl piperazin-1-yl)-3-oxobutanoate (III): Mix 0.012M of Br-EAA (II) and 0.01M of substituted benzylpiperazine in ethanol and reflux for 1-2 hours finally compleation of reaction was confirmed by TLC and separate.
Wikström, M., Holmgren, P. and Ahlner, J. (2004), ‘A2 (N-benzylpiperazine) a new drug of abuse in Sweden’, Journal of Analytical Toxicology, Volume 28, No 1, pp. 67–70.
Staack, R.F., Fritschi, G. and Maurer, H.H. (2002), ‘Studies on the metabolism and toxicological detection of the new designer drug N-benzylpiperazine in urine using gas chromatography-mass spectrometry’, Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences, Volume 773, No 1, pp. 35–46.
Wilkins, C., Girling, M. and Sweetsur, P. (2007), ‘The prevalence of use, dependency and harms of legal ‘party pills’ containing benzylpiperazine (BZP) and trifluorophenylmethylpiperazine (TFMPP) in New Zealand’, Journal of Substance Use, Volume 12, No 3, pp. 213–224.
Any material, compound, mixture, or preparation that contains any quantityof the following substances: (1) N-[1-benzyl-4-piperidyl]-N-phenylpropanamide (benzylfentanyl), its optical isomers, isomers, salts, and salts of isomers; (2) N-[1(2-thienyl) methyl-4-piperidyl]-N- phenylpropanamide (thenylfentanyl), its optical isomers, salts, and salts of isomers. (h) Synthetic cathinones.
(aa) "Narcotic drug" means any of the following, whether produceddirectly or indirectly by extraction from substances of vegetable origin,or independently by means of chemical synthesis, or by a combination ofextraction and chemical synthesis: (1) opium, opiates, derivatives of opium and opiates, including their isomers, esters, ethers, salts, and salts of isomers, esters, and ethers, whenever the existence of such isomers, esters, ethers, and salts is possible within the specific chemical designation; however the term "narcotic drug" does not include the isoquinoline alkaloids of opium; (2) (blank); (3) opium poppy and poppy straw; (4) coca leaves, except coca leaves and extracts of coca leaves from which substantially all of the cocaine and ecgonine, and their isomers, derivatives and salts, have been removed; (5) cocaine, its salts, optical and geometric isomers, and salts of isomers; (6) ecgonine, its derivatives, their salts, isomers, and salts of isomers; (7) any compound, mixture, or preparation which contains any quantity of any of the substances referred to in subparagraphs (1) through (6).
(z) "Manufacture" means the production, preparation, propagation,compounding, conversion or processing of a controlled substance other than methamphetamine, eitherdirectly or indirectly, by extraction from substances of natural origin,or independently by means of chemical synthesis, or by a combination ofextraction and chemical synthesis, and includes any packaging orrepackaging of the substance or labeling of its container, except thatthis term does not include: (1) by an ultimate user, the preparation or compounding of a controlled substance for his or her own use; or (2) by a practitioner, or his or her authorized agent under his or her supervision, the preparation, compounding, packaging, or labeling of a controlled substance: (a) as an incident to his or her administering or dispensing of a controlled substance in the course of his or her professional practice; or (b) as an incident to lawful research, teaching or chemical analysis and not for sale.
Negus, S.S., Baumann, M.H., Rothman, R.B., Mello, N.K., Blough, B.E. (2009), ‘Selective Suppression of Cocaine- versus Food-Maintained Responding by Monoamine Releasers in Rhesus Monkeys: Benzylpiperazine, (+)Phenmetrazine, and 4-Benzylpiperidine’, , Volume 329, pp. 272–281.
893.03(1)(c)190.; orcommits a felony of the first degree, which felony shall be known as “trafficking in synthetic cannabinoids,” punishable as provided in s.
Antibacterial activity: The antibacterial activity of test compounds shows that the newly synthesized Benzylpiperazine derivatives (IVP a–e) exhibited mild to moderate antibacterial activity against the test organisms employed in the present investigation. However, the degree of inhibition varied with the test compound and the test bacterium.
Campbell, H., Cline, W., Evans, M., Lloyd, J. and Peck, A.W. (1973), ‘Comparison of the effects of dexamphetamine and 1-benzylpiperazine in former addicts’, European Journal of Clinical Pharmacology, Volume 6, pp. 170–176.